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Anti-relapse effect of trametinib on a local minimal residual disease neuroblastoma mouse model

21 days ago   |   By Journal of Pediatric Surgery

We reported the in vitro and in vivo anti-tumor effects of trametinib, an MEK inhibitor, on neuroblastoma. However, long-term trametinib administration for bulky tumors failed to prevent local relapse. In this study, we established a local minimal residual disease model to develop an optimal clinical protocol.
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