Hospital
IL-1 inhibitors linked to ‘significant reduction' in COVID-19 mortality
12 days ago | By Healio
Interleukin-1 inhibitors are associated with a “significant reduction” in mortality among patients hospitalized with COVID-19, respiratory insufficiency and hyperinflammation, according to data published in The Lancet Rheumatology.
However, this association was not found with IL-6 inhibition, which was only effective in patients with “markedly high” C-reactive protein concentrations, the researchers noted.
“A subset of patients with severe COVID-19 develop a life-threatening hyperinflammatory response to the virus, which resembles the cytokine storm that develops
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