Pregnant

Category II non-reassuring fetal heart rate pattern and risk of admission to Neonatal Intensive Care Unit

1 month ago   |   By Journal of Pediatric and Neonatal Individualized Medicine

Background: The relationship between non-reassuring fetal heart rate pattern, acidemia at birth and neonatal morbidity remains unclear. Our aim was to compare low versus high pH cord blood infants of women detected with a Category II FHR pattern for which the impact is unclear. Methods: A prospective study of 185 low-risk pregnant women in labor at > 37 0/7 weeks of gestation with a singleton fetus was conducted at a single center. Category II trace was defined by the presence of tachycardia or bradycardia, variable and late decelerations, marked variability at least 30 minutes in the 120...
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Off-label and unlicensed drug treatments in Neonatal Intensive Care Units: a systematic review

1 month ago   |   By Journal of Pediatric and Neonatal Individualized Medicine

Newborns are particularly susceptible to off-label and unlicensed drug treatments, especially in the intensive care setting, inferring from dosing regimens and indications supported in older populations and built on non-neonatal pathophysiology. This use leads to unpredictable drug effectiveness and safety and, therefore, an increased probability of medication errors and adverse drug reactions. An extensive literature search was conducted in MEDLINE, Scopus, and Web of Science for papers published from 2011 to 2020 considering OLUL drug use in Neonatal Intensive Care Units. Of the 902...
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Cholangiopathy after severe COVID-19 may lead to liver injury, failure

Cholangiopathy after severe COVID-19 may lead to liver injury, failure

For patients with severe COVID-19, cholangiopathy was a late complication with potential for progressive biliary injury or liver failure, according to a study published in the... Read more ...

Mississippi woman pleads others to get vaccinated as her husband is hospitalized

Mississippi woman pleads others to get vaccinated as her husband is hospitalized

William Thomas Ball, 51, has been hospitalized with COVID-19 in Jackson, Mississippi after refusing to get vaccinated. Now his wife, Alicia, is asking for others in her... Read more ...

Covid England: Cases are now falling in ALL age groups, official data reveals

Covid England: Cases are now falling in ALL age groups, official data reveals

EXCLUSIVE: Covid cases are falling in all age groups, and dropping fastest among adults in their twenties according to data from the Department of Health. Read more ...

Lumbar artificial disc yielded positive 7-year outcomes for degenerative...

Lumbar artificial disc yielded positive 7-year outcomes for degenerative disc disease

For total disc replacement in patients with degenerative disc disease, an artificial disc is a safe option that improves pain relief, function, range of motion and decreases in... Read more ...

FDA clamps down on imported shark fins, cantaloupes, mushrooms and more

FDA clamps down on imported shark fins, cantaloupes, mushrooms and more

The Food and Drug Administration uses import alerts to enforce U.S. food safety regulations for food from foreign countries. The agency updates and modifies the alerts as... Read more ...

FDA TechTalk podcast episode to focus on whole genome sequencing

FDA TechTalk podcast episode to focus on whole genome sequencing

Nowadays, it seems rare to find someone or some entity without a podcast, and the Food and Drug Administration is no exception. The TechTalk podcast is hosted by the FDA and... Read more ...

COVID Breakthrough Cases Ran the Gamut in Healthcare Workers

COVID Breakthrough Cases Ran the Gamut in Healthcare Workers

Breakthrough COVID-19 cases in fully vaccinated healthcare workers were rare, and generally were associated with the individual's immune response to the vaccine in the early... Read more ...

Some IBD Treatments in Pregnancy Had No Effect on Kids' Infection Risk

Some IBD Treatments in Pregnancy Had No Effect on Kids' Infection Risk

Exposure to immunosuppressive monotherapies in utero did not increase serious infection risks in young children born to mothers with inflammatory bowel disease , but the same... Read more ...

FDA issues complete response letter for retifanlimab for anal cancer

FDA issues complete response letter for retifanlimab for anal cancer

The FDA issued a complete response letter to Incyte indicating it cannot approve the company's biologics license application that seeks approval of retifanlimab for certain... Read more ...

Bristol Myers Squibb withdraws liver cancer indication for nivolumab

Bristol Myers Squibb withdraws liver cancer indication for nivolumab

Bristol Myers Squibb in consultation with the FDA voluntarily withdrew the indication for nivolumab as monotherapy for patients with hepatocellular carcinoma previously treated... Read more ...