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New England Journal of Medicine

 http://www.nejm.org/

VX-445-TEZACAFTOR-IVACAFTOR IN PATIENTS WITH CYSTIC FIBROSIS AND ONE OR TWO PHE508DEL ALLELES

Cystic fibrosis is a rare, progressive, lethal, recessive genetic disease caused by diminished quantity or function of the cystic fibrosis...

VX-659-TEZACAFTOR-IVACAFTOR IN PATIENTS WITH CYSTIC FIBROSIS AND ONE OR TWO PHE508DEL ALLELES

Cystic fibrosis is a serious, autosomal-recessive, multisystem disease that affects approximately 80,000 people worldwide and is associated...

 
 
 

TRIPLE CFTR MODULATOR THERAPY FOR CYSTIC FIBROSIS

Cystic fibrosis is one of the most common life-threatening autosomal recessive disorders, affecting approximately 80,000 children and...

HEMOGLOBINOPATHIES IN THE FETAL POSITION

The hemoglobinopathies, disorders that are caused by mutations in genes that encode the "adult" globins, exert a devastating toll on...

 
 
 

VARIATION IN CHILDHOOD DIARRHEAL MORBIDITY AND MORTALITY IN AFRICA, 2000-2015

Diarrhea-related deaths in children are largely preventable. Unfortunately, the burden of diarrhea remains high and inadequately characterized...

CASE 29-2018: A 31-YEAR-OLD WOMAN WITH INFERTILITY

Presentation of Case. Dr. Caitlin Sacha : A 31-year-old woman with infertility was referred to the fertility center of this hospital...

 
 
 

ACCELERATION OF BMI IN EARLY CHILDHOOD AND RISK OF SUSTAINED OBESITY

The overall prevalence of childhood obesity remains very high, and the prevalence of very high levels of body-mass index for age in...

DETERMINANTS OF RISK FOR CHILDHOOD OBESITY

The body-fat content of a healthy full-term infant rises sharply from 10 to 14% at birth to 25 to 30% at 6 months of age, with a consequent...

 
 
 

ACNE VULGARIS

Foreword. This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies...

NEUROBLASTOMA AND HISTONE DEMETHYLATION

Neuroblastoma is a childhood cancer of the sympathetic nervous system, with a propensity for widespread metastasis and aggressive clinical...

 
 
 

ACUTE DACRYOCYSTITIS

A 4-week-old boy was brought to the emergency department after having drainage from both eyes for 2 days and redness and swelling under...

SAFETY AND SIDE EFFECTS OF RIFAMPIN VERSUS ISONIAZID IN CHILDREN

Tuberculosis is a major global health problem, with an estimated 10.4 million new cases worldwide in 2016; of these cases, 1.0 million...

 
 
 

A ROAD MAP FOR SUSTAINING HEALTHY EATING BEHAVIOR

Diet-related diseases such as obesity, cardiovascular disease, and type 2 diabetes are among the most common, costly, and preventable...

BALOXAVIR MARBOXIL FOR UNCOMPLICATED INFLUENZA IN ADULTS AND ADOLESCENTS

Additional effective antiviral agents are needed for the treatment and prevention of influenza virus infections. Two classes of agents,...

 
 
 

A STEP FORWARD IN THE TREATMENT OF INFLUENZA

For many years, antiviral treatment of influenza has consisted of monotherapy with a neuraminidase inhibitor. The Food and Drug Administration...

NEURAL-TUBE DEFECTS WITH DOLUTEGRAVIR TREATMENT FROM THE TIME OF CONCEPTION

To the Editor: Since August 2014, the Botswana Harvard AIDS Institute Partnership has conducted birth outcome surveillance at eight...

 
 
 

VITAMIN D SUPPLEMENTATION IN PREGNANCY AND LACTATION AND INFANT GROWTH

Infants who are small for gestational age or have impaired postnatal linear growth continue to be of major concern with regard to public...

OUTCOMES OF CARDIAC SCREENING IN ADOLESCENT SOCCER PLAYERS

Sudden cardiac death in a seemingly healthy athlete invariably prompts discussion about possible preventative screening strategies....

 
 
 

WHISTLING COUGH

A 4-year-old boy presented to the otorhinolaryngology outpatient clinic with a 2-day history of persistent cough that had an intermittent...

ESOPHAGEAL ATRESIA AND TRACHEOESOPHAGEAL FISTULA

An infant had an apneic episode at birth and received positive-pressure ventilation in the delivery room during neonatal resuscitation....

 
 
 



World Diabetes Day: Obesity Among Diabetics On the Rise in Urban India

World Diabetes Day: Obesity Among Diabetics On the Rise in Urban India

Obesity among diabetics is on the rise in India and majority of patients prefer to have fewer large meals than small meals, reveals a new study on type 2 diabetes patients in... Read more ...

Hope for Parkinson's patients as scientists discover how to destroy toxic...

Hope for Parkinson's patients as scientists discover how to destroy toxic clumps in their brains

Researchers from Georgetown University Medical Center in Washington DC have discovered blocking a certain protein in the brain can clear away nerve damaging build-ups. Read more ...

Thousands of diabetes patients to get life-changing glucose monitors

Thousands of diabetes patients to get life-changing glucose monitors

Simon Stevens, chief executive of NHS England, has stepped in to end a ‘postcode lottery' which saw many people denied access to the life-changing devices as used by Theresa... Read more ...

Nanomagnets and Moths Can Save Lives: Here's How

Nanomagnets and Moths Can Save Lives: Here's How

Novel technology that relies on a moth-infecting virus and nanomagnets can be used to edit defective genes that give rise to diseases such as sickle cell, cystic fibrosis and... Read more ...

Drinking three cups of coffee a day slashes your risk of developing type 2...

Drinking three cups of coffee a day slashes your risk of developing type 2 diabetes by a quarter

Researchers trawled through 30 studies, which involved nearly 1.2million people, to make the conclusion. They presented their findings at a conference in Berlin. Read more ...

New Strategy to Reduce Breast Cancer Bone Metastasis Discovered

New Strategy to Reduce Breast Cancer Bone Metastasis Discovered

Uncovering a new mechanism that promotes growth of breast cancer bone metastasis has revealed a potential Achilles' heel for these cancer cells. Read more ...

Nitric Oxide Technology Can Heal Diabetic Foot Ulcers Much Faster

Nitric Oxide Technology Can Heal Diabetic Foot Ulcers Much Faster

New nitric oxide-releasing technology has the potential to reduce the healing time of diabetic foot ulcers. Read more ...

Scientists: Taking EPA and DHA omega-3s reduces your risk of cardiac death

Scientists: Taking EPA and DHA omega-3s reduces your risk of cardiac death

Omega-3 fatty acids can help reduce your risk of heart disease - even if the mainstream media is trying to say otherwise. While Big Pharma is trying to get everyone under the... Read more ...

Organic fertilizer can be used to increase crop yield in plants grown in...

Organic fertilizer can be used to increase crop yield in plants grown in rotation

A study published in the journal Biological Agriculture & Horticulture assessed soil nitrogen oxidation through field incubation, and analyzed the rate of nitrogen release by... Read more ...

The importance of magnesium in the prevention and treatment of Type 2 diabetes

The importance of magnesium in the prevention and treatment of Type 2 diabetes

Estimates suggest that over 30 million Americans have some form of diabetes, and it is one of the leading causes of death in the United States. Type 2 diabetes is on the rise... Read more ...