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Entrectinib induces ‘rapid and durable' responses in pediatric tumors with gene fusions

10 days ago   |   By Healio

Children with central nervous system or other solid tumors with specific gene fusions responded to treatment with the investigational tyrosine kinase inhibitor entrectinib, according to results of a phase 1/1b trial scheduled for presentation at ASCO Annual Meeting.
All 12 patients who responded to treatment with entrectinib had NTRK1/2/3, ROS1 or ALK gene fusions or an ALK mutation. The responses were “rapid and durable,” according to Giles W. Robinson, MD, a pediatric neuro-oncologist at St. Jude Children's Research Hospital in Memphis and one of the
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'Striking' Responses in Pediatric Solid Tumors With Entrectinib

10 days ago   |   By Medscape

A novel targeted therapy produced impressive responses among children and adolescents with rare tumors that had progressed or were refractory to previous therapy.
Medscape Medical News
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