Vitamins

VITAL: Vitamin D, omega-3 fail to reduce major CV events, cancer

6 monthes ago   |   By Healio

CHICAGO - In the large-scale VITAL trial, neither omega-3 nor vitamin D supplements for primary prevention reduced major CV events or development of invasive cancers compared with placebo over 5 years of follow-up.
The 25,871-patient, placebo-controlled trial had a 2x2 factorial design, by which patients were randomly assigned vitamin D3 2,000 IU per day and omega-3 fatty acids 1 g per day, each compared with placebo.
VITAL had two primary endpoints: major CV events, defined as a composite of MI, stroke or death from CV causes, and invasive cancer of any type. Patients
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REDUCE-IT: Icosapent ethyl reduces ischemic events in high-risk patients

6 monthes ago   |   By Healio

CHICAGO - In patients with elevated triglycerides at high CV risk despite statin therapy, icosapent ethyl was superior to placebo for reducing risk for ischemic events, according to results of the anticipated REDUCE-IT trial.
The trial of icosapent ethyl , a pharmaceutical-grade omega-3 fatty acid, enrolled 8,179 patients who had fasting triglycerides 135 mg/dL to 499 mg/dL despite taking statins and who had established CVD or diabetes plus other risk factors. Patients were assigned icosapent ethyl 2 g twice
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